In the study “Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance,” researchers explore the role of gut microbes in colorectal cancer (CRC) and how it’s possible that Reuterin suppresses colorectal cancer. They focus on microbial metabolites’ impact on CRC, which remains largely unexplored. The team studies fecal metabolites from mouse models with different levels of colon tumorigenesis mutations. They find that metabolites from healthy mice or humans hinder tumor growth. This effect is less in mice and humans with CRC.
The study reveals a decrease in Lactobacillus reuteri and its metabolite, reuterin, in both mouse and human CRC. Reuterin suppresses colorectal cancer by changing the redox balance, cutting down the proliferation and survival of colon cancer cells. It causes selective protein oxidation and slows ribosomal biogenesis and protein translation. Adding Lactobacillus reuteri from outside limits colon tumor growth, boosts tumor reactive oxygen species, and reduces protein translation in live subjects.
The findings suggest that a healthy gut microbiome, especially Lactobacillus reuteri, protects against CRC through the exchange of microbial metabolites.
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